World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
SPTLC1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight52030Da
Protein NameSerine palmitoyltransferase 1
Human Gene Id10558
Human Swiss Prot NoO15269
Mouse Gene Id268656
Mouse Swiss Prot NoO35704
SpecificitySPTLC1 Polyclonal Antibody detects endogenous levels of SPTLC1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSPTLC1; LCB1; Serine palmitoyltransferase 1; Long chain base biosynthesis protein 1; LCB 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1
Observed Band(KD)52
Functioncatalytic activity:Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2).,cofactor:Pyridoxal phosphate.,disease:Defects in SPTLC1 are the cause of hereditary sensory and autonomic neuropathy type 1 (HSAN1) [MIM:162400]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN1 is an autosomal dominant axonal neuropathy with onset in the second or third decades. Initial symptoms are loss of pain, touch, heat, and cold sensation over the feet, followed by distal muscle wasting and weakness. Loss of pain sensation leads to chronic skin ulcers and distal amputations.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass membrane protein .
ExpressionWidely expressed. Not detected in small intestine.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from SPTLC1 . at AA range: 411-460
Gene NameSPTLC1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundserine palmitoyltransferase long chain base subunit 1(SPTLC1) Homo sapiens This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013],
Conjugated Antibody
This product is also available conjugated. Format: E20-75232-Conjugate. Price: $485 / Size: 100μl.
E20-75232-FITC$485 / 100μlE20-75232-Biotin$485 / 100μlE20-75232-HRP$485 / 100μlE20-75232-AP$485 / 100μlE20-75232-AF350$485 / 100μlE20-75232-AF405M$485 / 100μlE20-75232-AF488$485 / 100μlE20-75232-AF514$485 / 100μlE20-75232-AF532$485 / 100μlE20-75232-AF555$485 / 100μlE20-75232-AF568$485 / 100μlE20-75232-AF405S$485 / 100μlE20-75232-AF405L$485 / 100μlE20-75232-AF546$485 / 100μlE20-75232-AF594$485 / 100μlE20-75232-AF610$485 / 100μlE20-75232-AF635$485 / 100μlE20-75232-AF647$485 / 100μlE20-75232-AF680$485 / 100μlE20-75232-AF700$485 / 100μlE20-75232-AF750$485 / 100μlE20-75232-AF790$485 / 100μlE20-75232-APC$485 / 100μlE20-75232-PE$485 / 100μlE20-75232-Cy3$485 / 100μlE20-75232-Cy5$485 / 100μlE20-75232-Cy5.5$485 / 100μlE20-75232-Cy7$485 / 100μlE20-75232-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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