World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
DPYD Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight112750Da
Protein NameDihydropyrimidine dehydrogenase [NADP(+)]
Human Gene Id1806
Human Swiss Prot NoQ12882
Mouse Gene Id99586
Mouse Swiss Prot NoQ8CHR6
Rat Gene Id81656
Rat Swiss Prot NoO89000
SpecificityDPYD Polyclonal Antibody detects endogenous levels of DPYD protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameDPYD; Dihydropyrimidine dehydrogenase [NADP(+)]; DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase
Observed Band(KD)120
Functioncatalytic activity:5,6-dihydrouracil + NADP(+) = uracil + NADPH.,cofactor:Binds 2 4Fe-4S clusters. Contains approximately 33 iron atoms per molecule.,cofactor:Binds 2 FAD.,cofactor:Binds 2 FMN.,disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.,function:Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.
Subcellular LocationCytoplasm.
ExpressionFound in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human DPYD. AA range:351-400
Gene NameDPYD
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgrounddihydropyrimidine dehydrogenase(DPYD) Homo sapiens The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-75227-Conjugate. Price: $485 / Size: 100μl.
E20-75227-FITC$485 / 100μlE20-75227-Biotin$485 / 100μlE20-75227-HRP$485 / 100μlE20-75227-AP$485 / 100μlE20-75227-AF350$485 / 100μlE20-75227-AF405M$485 / 100μlE20-75227-AF488$485 / 100μlE20-75227-AF514$485 / 100μlE20-75227-AF532$485 / 100μlE20-75227-AF555$485 / 100μlE20-75227-AF568$485 / 100μlE20-75227-AF405S$485 / 100μlE20-75227-AF405L$485 / 100μlE20-75227-AF546$485 / 100μlE20-75227-AF594$485 / 100μlE20-75227-AF610$485 / 100μlE20-75227-AF635$485 / 100μlE20-75227-AF647$485 / 100μlE20-75227-AF680$485 / 100μlE20-75227-AF700$485 / 100μlE20-75227-AF750$485 / 100μlE20-75227-AF790$485 / 100μlE20-75227-APC$485 / 100μlE20-75227-PE$485 / 100μlE20-75227-Cy3$485 / 100μlE20-75227-Cy5$485 / 100μlE20-75227-Cy5.5$485 / 100μlE20-75227-Cy7$485 / 100μlE20-75227-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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