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Cell Signal Transduction Research Antibodies
SHIP-2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight138585Da
Protein NamePhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Human Gene Id3636
Human Swiss Prot NoO15357
Mouse Gene Id16332
Mouse Swiss Prot NoQ6P549
Rat Gene Id65038
Rat Swiss Prot NoQ9WVR3
SpecificitySHIP-2 Polyclonal Antibody detects endogenous levels of SHIP-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameINPPL1; SHIP2; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2
Observed Band(KD)130
Functioncatalytic activity:Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 3,4-bisphosphate + phosphate.,disease:Defects in INPPL1 may be a cause of susceptibility to type 2 diabetes mellitus non-insulin dependent (NIDDM) [MIM:125853].,disease:Genetic variations in INPPL1 may be a cause of susceptibility to metabolic syndrome. Metabolic syndrome is characterized by diabetes, insulin resistance, hypertension, and hypertriglyceridemia is absent.,domain:The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain.,domain:The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or FCGR2A. It also mediates the interaction with p130Cas/BCAR1.,enzyme regulation:Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane. Enzymatic activity is enhanced in the
Subcellular LocationCytoplasm, cytosol . Cytoplasm, cytoskeleton. Membrane ; Peripheral membrane protein. Cell projection, filopodium . Cell projection, lamellipodium . Nucleus . Nucleus speckle . Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring.
ExpressionWidely expressed, most prominently in skeletal muscle, heart and brain. Present in platelets. Expressed in transformed myeloid cells and in primary macrophages, but not in peripheral blood monocytes.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human INPPL1. AA range:351-400
Gene NameINPPL1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundinositol polyphosphate phosphatase like 1(INPPL1) Homo sapiens The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-75226-Conjugate. Price: $485 / Size: 100μl.
E20-75226-FITC$485 / 100μlE20-75226-Biotin$485 / 100μlE20-75226-HRP$485 / 100μlE20-75226-AP$485 / 100μlE20-75226-AF350$485 / 100μlE20-75226-AF405M$485 / 100μlE20-75226-AF488$485 / 100μlE20-75226-AF514$485 / 100μlE20-75226-AF532$485 / 100μlE20-75226-AF555$485 / 100μlE20-75226-AF568$485 / 100μlE20-75226-AF405S$485 / 100μlE20-75226-AF405L$485 / 100μlE20-75226-AF546$485 / 100μlE20-75226-AF594$485 / 100μlE20-75226-AF610$485 / 100μlE20-75226-AF635$485 / 100μlE20-75226-AF647$485 / 100μlE20-75226-AF680$485 / 100μlE20-75226-AF700$485 / 100μlE20-75226-AF750$485 / 100μlE20-75226-AF790$485 / 100μlE20-75226-APC$485 / 100μlE20-75226-PE$485 / 100μlE20-75226-Cy3$485 / 100μlE20-75226-Cy5$485 / 100μlE20-75226-Cy5.5$485 / 100μlE20-75226-Cy7$485 / 100μlE20-75226-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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