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Cell Signal Transduction Research Antibodies
CYP11A1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight(Da): 60102
Protein NameCholesterol side-chain cleavage enzyme mitochondrial
Human Gene Id1583
Human Swiss Prot NoP05108
Mouse Swiss Prot NoQ9QZ82
SpecificityCYP11A1 Polyclonal Antibody detects endogenous levels of CYP11A1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCYP11A1; CYP11A; Cholesterol side-chain cleavage enzyme, mitochondrial; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)
Observed Band(KD)57
Functioncatalytic activity:Cholesterol + reduced adrenal ferredoxin + O(2) = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H(2)O.,cofactor:Heme group.,disease:Defects in CYP11A1 are a cause of congenital adrenal insufficiency (CAI).,disease:Defects in CYP11A1 are a cause of congenital lipoid adrenal hyperplasia (CLAH) [MIM:201710]; also called lipoid CAH. CLAH is the most severe form of adrenal hyperplasia. This autosomal recessive and potentially lethal condition includes the onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma renin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. CLAH is a rare disease, except in Japan and Korea where it accounts for a significant
Subcellular LocationMitochondrion inner membrane ; Peripheral membrane protein . Localizes to the matrix side of the mitochondrion inner membrane. .
ExpressionBrain,Choriocarcinoma,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human CYP11A1. AA range:411-460
Gene NameCYP11A1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundcytochrome P450 family 11 subfamily A member 1(CYP11A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75223-Conjugate. Price: $485 / Size: 100μl.
E20-75223-FITC$485 / 100μlE20-75223-Biotin$485 / 100μlE20-75223-HRP$485 / 100μlE20-75223-AP$485 / 100μlE20-75223-AF350$485 / 100μlE20-75223-AF405M$485 / 100μlE20-75223-AF488$485 / 100μlE20-75223-AF514$485 / 100μlE20-75223-AF532$485 / 100μlE20-75223-AF555$485 / 100μlE20-75223-AF568$485 / 100μlE20-75223-AF405S$485 / 100μlE20-75223-AF405L$485 / 100μlE20-75223-AF546$485 / 100μlE20-75223-AF594$485 / 100μlE20-75223-AF610$485 / 100μlE20-75223-AF635$485 / 100μlE20-75223-AF647$485 / 100μlE20-75223-AF680$485 / 100μlE20-75223-AF700$485 / 100μlE20-75223-AF750$485 / 100μlE20-75223-AF790$485 / 100μlE20-75223-APC$485 / 100μlE20-75223-PE$485 / 100μlE20-75223-Cy3$485 / 100μlE20-75223-Cy5$485 / 100μlE20-75223-Cy5.5$485 / 100μlE20-75223-Cy7$485 / 100μlE20-75223-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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