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Cell Signal Transduction Research Antibodies
Neuregulin-2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight91679Da
Protein NamePro-neuregulin-2 membrane-bound isoform
Human Gene Id9542
Human Swiss Prot NoO14511
Mouse Swiss Prot NoP56974
Rat Gene Id432361
Rat Swiss Prot NoO35569
SpecificityNeuregulin-2 Polyclonal Antibody detects endogenous levels of Neuregulin-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNRG2; NTAK; Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2
Observed Band(KD)90
Functiondomain:ERBB receptor binding is elicited entirely by the EGF-like domain.,domain:The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.,function:Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.,PTM:Extensive glycosylation precedes the proteolytic cleavage.,PTM:Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.,similarity:Belongs to the neuregulin family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,s
Subcellular Location[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .; [Neuregulin-2]: Secreted .
ExpressionRestricted to the cerebellum in the adult.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human NRG2. AA range:361-410
Gene NameNRG2
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundneuregulin 2(NRG2) Homo sapiens This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-75215-Conjugate. Price: $485 / Size: 100μl.
E20-75215-FITC$485 / 100μlE20-75215-Biotin$485 / 100μlE20-75215-HRP$485 / 100μlE20-75215-AP$485 / 100μlE20-75215-AF350$485 / 100μlE20-75215-AF405M$485 / 100μlE20-75215-AF488$485 / 100μlE20-75215-AF514$485 / 100μlE20-75215-AF532$485 / 100μlE20-75215-AF555$485 / 100μlE20-75215-AF568$485 / 100μlE20-75215-AF405S$485 / 100μlE20-75215-AF405L$485 / 100μlE20-75215-AF546$485 / 100μlE20-75215-AF594$485 / 100μlE20-75215-AF610$485 / 100μlE20-75215-AF635$485 / 100μlE20-75215-AF647$485 / 100μlE20-75215-AF680$485 / 100μlE20-75215-AF700$485 / 100μlE20-75215-AF750$485 / 100μlE20-75215-AF790$485 / 100μlE20-75215-APC$485 / 100μlE20-75215-PE$485 / 100μlE20-75215-Cy3$485 / 100μlE20-75215-Cy5$485 / 100μlE20-75215-Cy5.5$485 / 100μlE20-75215-Cy7$485 / 100μlE20-75215-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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