World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Fascin 1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight54230Da
Protein NameFascin
Human Gene Id6624
Human Swiss Prot NoQ16658
Mouse Gene Id14086
Mouse Swiss Prot NoQ61553
Rat Gene Id683788
Rat Swiss Prot NoP85845
SpecificityFascin 1 Polyclonal Antibody detects endogenous levels of Fascin 1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameFSCN1; FAN1; HSN; SNL; Fascin; 55 kDa actin-bundling protein; Singed-like protein; p55
Observed Band(KD)55
Functiondisease:Marks and mediates breast cancer metastasis to the lungs. FSCN1 is not functionally validated but achieves the highest statistical significance (P less than 0.000001). Those subjects expressing the lung metastasis signature have a significantly poorer lung metastasis-free survival, but not bone metastasis-free survival, compared to subjects without the signature.,function:Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Probably involved in the assembly of actin filament bundles present in microspikes, membrane ruffles, and stress fibers.,PTM:Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.,similarity:Belongs to the fascin family.,subunit:Associates with beta-catenin.,tissue specificity:Ubiquitous.,
Subcellular LocationCytoplasm, cytosol . Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, stress fiber . Cell projection, filopodium . Cell projection, invadopodium . Cell projection, microvillus . Cell junction . Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity). .
ExpressionUbiquitous.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human FSCN1. AA range:261-310
Gene NameFSCN1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundfascin actin-bundling protein 1(FSCN1) Homo sapiens This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75212-Conjugate. Price: $485 / Size: 100μl.
E20-75212-FITC$485 / 100μlE20-75212-Biotin$485 / 100μlE20-75212-HRP$485 / 100μlE20-75212-AP$485 / 100μlE20-75212-AF350$485 / 100μlE20-75212-AF405M$485 / 100μlE20-75212-AF488$485 / 100μlE20-75212-AF514$485 / 100μlE20-75212-AF532$485 / 100μlE20-75212-AF555$485 / 100μlE20-75212-AF568$485 / 100μlE20-75212-AF405S$485 / 100μlE20-75212-AF405L$485 / 100μlE20-75212-AF546$485 / 100μlE20-75212-AF594$485 / 100μlE20-75212-AF610$485 / 100μlE20-75212-AF635$485 / 100μlE20-75212-AF647$485 / 100μlE20-75212-AF680$485 / 100μlE20-75212-AF700$485 / 100μlE20-75212-AF750$485 / 100μlE20-75212-AF790$485 / 100μlE20-75212-APC$485 / 100μlE20-75212-PE$485 / 100μlE20-75212-Cy3$485 / 100μlE20-75212-Cy5$485 / 100μlE20-75212-Cy5.5$485 / 100μlE20-75212-Cy7$485 / 100μlE20-75212-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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