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Cell Signal Transduction Research Antibodies
CD68 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight37408Da
Protein NameMacrosialin
Human Gene Id968
Human Swiss Prot NoP34810
Mouse Swiss Prot NoP31996
SpecificityCD68 Polyclonal Antibody detects endogenous levels of CD68 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD68; Macrosialin; Gp110; CD68
Observed Band(KD)37
Functionfunction:Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Bind to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes, lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.,PTM:N- and O-glycosylated.,similarity:Belongs to the LAMP family.,tissue specificity:Highly expressed by blood monocytes and tissue macrophages. Also expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.,
Subcellular Location[Isoform Short]: Cell membrane; Single-pass type I membrane protein.; [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
ExpressionHighly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD68. AA range:171-220
Gene NameCD68
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
BackgroundCD68 molecule(CD68) Homo sapiens This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75210-Conjugate. Price: $485 / Size: 100μl.
E20-75210-FITC$485 / 100μlE20-75210-Biotin$485 / 100μlE20-75210-HRP$485 / 100μlE20-75210-AP$485 / 100μlE20-75210-AF350$485 / 100μlE20-75210-AF405M$485 / 100μlE20-75210-AF488$485 / 100μlE20-75210-AF514$485 / 100μlE20-75210-AF532$485 / 100μlE20-75210-AF555$485 / 100μlE20-75210-AF568$485 / 100μlE20-75210-AF405S$485 / 100μlE20-75210-AF405L$485 / 100μlE20-75210-AF546$485 / 100μlE20-75210-AF594$485 / 100μlE20-75210-AF610$485 / 100μlE20-75210-AF635$485 / 100μlE20-75210-AF647$485 / 100μlE20-75210-AF680$485 / 100μlE20-75210-AF700$485 / 100μlE20-75210-AF750$485 / 100μlE20-75210-AF790$485 / 100μlE20-75210-APC$485 / 100μlE20-75210-PE$485 / 100μlE20-75210-Cy3$485 / 100μlE20-75210-Cy5$485 / 100μlE20-75210-Cy5.5$485 / 100μlE20-75210-Cy7$485 / 100μlE20-75210-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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