Product Information
Molecular Weight30025Da
Protein NameCalbindin
Human Gene Id793
Human Swiss Prot NoP05937
Mouse Gene Id12307
Mouse Swiss Prot NoP12658
Rat Gene Id83839
Rat Swiss Prot NoP07171
SpecificityCalbindin D28K Polyclonal Antibody detects endogenous levels of Calbindin D28K protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCALB1; CAB27; Calbindin; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type
Observed Band(KD)30
Functiondomain:This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.,function:Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.,online information:Calbindin entry,similarity:Belongs to the calbindin family.,similarity:Contains 5 EF-hand domains.,subunit:Interacts with RANBP9.,
Subcellular Locationnucleus,cytosol,axon,dendrite,neuronal cell body,terminal bouton,synapse,extracellular exosome,
ExpressionBrain,Cerebellum,Kidney,Lung,Substantia nigra,
Backgroundcalbindin 1(CALB1) Homo sapiens The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015],