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Cell Signal Transduction Research Antibodies
ADM Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight20420Da
Protein NameADM
Human Gene Id133
Human Swiss Prot NoP35318
Mouse Swiss Prot NoP97297
Rat Gene Id25026
Rat Swiss Prot NoP43145
SpecificityADM Polyclonal Antibody detects endogenous levels of ADM protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameADM; AM; ADM
Observed Band(KD)20
Functionfunction:AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.,similarity:Belongs to the adrenomedullin family.,tissue specificity:Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.,
Subcellular LocationSecreted.
ExpressionHighest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ADM. AA range:101-150
Gene NameADM
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundadrenomedullin(ADM) Homo sapiens The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-75202-Conjugate. Price: $485 / Size: 100μl.
E20-75202-FITC$485 / 100μlE20-75202-Biotin$485 / 100μlE20-75202-HRP$485 / 100μlE20-75202-AP$485 / 100μlE20-75202-AF350$485 / 100μlE20-75202-AF405M$485 / 100μlE20-75202-AF488$485 / 100μlE20-75202-AF514$485 / 100μlE20-75202-AF532$485 / 100μlE20-75202-AF555$485 / 100μlE20-75202-AF568$485 / 100μlE20-75202-AF405S$485 / 100μlE20-75202-AF405L$485 / 100μlE20-75202-AF546$485 / 100μlE20-75202-AF594$485 / 100μlE20-75202-AF610$485 / 100μlE20-75202-AF635$485 / 100μlE20-75202-AF647$485 / 100μlE20-75202-AF680$485 / 100μlE20-75202-AF700$485 / 100μlE20-75202-AF750$485 / 100μlE20-75202-AF790$485 / 100μlE20-75202-APC$485 / 100μlE20-75202-PE$485 / 100μlE20-75202-Cy3$485 / 100μlE20-75202-Cy5$485 / 100μlE20-75202-Cy5.5$485 / 100μlE20-75202-Cy7$485 / 100μlE20-75202-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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