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Cell Signal Transduction Research Antibodies
ASIC3 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight58905Da
Protein NameAcid-sensing ion channel 3
Human Gene Id9311
Human Swiss Prot NoQ9UHC3
Mouse Swiss Prot NoQ6X1Y6
SpecificityASIC3 Polyclonal Antibody detects endogenous levels of ASIC3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameASIC3; ACCN3; SLNAC1; TNAC1; Acid-sensing ion channel 3; ASIC3; hASIC3; Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1; hTNaC1
Observed Band(KD)58
Functiondevelopmental stage:Expressed in fetal tissues, expression increases in lung and kidney adult tissues.,domain:The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1.,function:Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.,miscellaneous:Potentiated by FMRFamide-related neuropeptides. Sensitized and potentiated by NPSF. Regulated by lactate and Ca(2+). Inhibited by anti-inflammatory drugs, like salicylic acid (By similarity). Sensitized and potent
Subcellular LocationCell membrane ; Multi-pass membrane protein . Cytoplasm . Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). .
ExpressionExpressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ASIC3. AA range:191-240
Gene NameASIC3
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundacid sensing ion channel subunit 3(ASIC3) Homo sapiens This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012],
Conjugated Antibody
This product is also available conjugated. Format: E20-75200-Conjugate. Price: $485 / Size: 100μl.
E20-75200-FITC$485 / 100μlE20-75200-Biotin$485 / 100μlE20-75200-HRP$485 / 100μlE20-75200-AP$485 / 100μlE20-75200-AF350$485 / 100μlE20-75200-AF405M$485 / 100μlE20-75200-AF488$485 / 100μlE20-75200-AF514$485 / 100μlE20-75200-AF532$485 / 100μlE20-75200-AF555$485 / 100μlE20-75200-AF568$485 / 100μlE20-75200-AF405S$485 / 100μlE20-75200-AF405L$485 / 100μlE20-75200-AF546$485 / 100μlE20-75200-AF594$485 / 100μlE20-75200-AF610$485 / 100μlE20-75200-AF635$485 / 100μlE20-75200-AF647$485 / 100μlE20-75200-AF680$485 / 100μlE20-75200-AF700$485 / 100μlE20-75200-AF750$485 / 100μlE20-75200-AF790$485 / 100μlE20-75200-APC$485 / 100μlE20-75200-PE$485 / 100μlE20-75200-Cy3$485 / 100μlE20-75200-Cy5$485 / 100μlE20-75200-Cy5.5$485 / 100μlE20-75200-Cy7$485 / 100μlE20-75200-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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