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Cell Signal Transduction Research Antibodies
ACBP Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight10044Da
Protein NameAcyl-CoA-binding protein
Human Gene Id1622
Human Swiss Prot NoP07108
Mouse Gene Id13167
Mouse Swiss Prot NoP31786
Rat Gene Id25045
Rat Swiss Prot NoP11030
SpecificityACBP Polyclonal Antibody detects endogenous levels of ACBP protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameDBI; Acyl-CoA-binding protein; ACBP; Diazepam-binding inhibitor; DBI; Endozepine; EP
Observed Band(KD)10
Functionfunction:Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.,similarity:Belongs to the ACBP family.,similarity:Contains 1 ACB (acyl-CoA-binding) domain.,subunit:Monomer.,
Subcellular LocationEndoplasmic reticulum . Golgi apparatus . Golgi localization is dependent on ligand binding (PubMed:17953517). .
ExpressionIsoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human DBI. AA range:38-87
Gene NameDBI
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgrounddiazepam binding inhibitor, acyl-CoA binding protein(DBI) Homo sapiens This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoform
Conjugated Antibody
This product is also available conjugated. Format: E20-75199-Conjugate. Price: $485 / Size: 100μl.
E20-75199-FITC$485 / 100μlE20-75199-Biotin$485 / 100μlE20-75199-HRP$485 / 100μlE20-75199-AP$485 / 100μlE20-75199-AF350$485 / 100μlE20-75199-AF405M$485 / 100μlE20-75199-AF488$485 / 100μlE20-75199-AF514$485 / 100μlE20-75199-AF532$485 / 100μlE20-75199-AF555$485 / 100μlE20-75199-AF568$485 / 100μlE20-75199-AF405S$485 / 100μlE20-75199-AF405L$485 / 100μlE20-75199-AF546$485 / 100μlE20-75199-AF594$485 / 100μlE20-75199-AF610$485 / 100μlE20-75199-AF635$485 / 100μlE20-75199-AF647$485 / 100μlE20-75199-AF680$485 / 100μlE20-75199-AF700$485 / 100μlE20-75199-AF750$485 / 100μlE20-75199-AF790$485 / 100μlE20-75199-APC$485 / 100μlE20-75199-PE$485 / 100μlE20-75199-Cy3$485 / 100μlE20-75199-Cy5$485 / 100μlE20-75199-Cy5.5$485 / 100μlE20-75199-Cy7$485 / 100μlE20-75199-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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