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Cell Signal Transduction Research Antibodies
CyPA Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight18012Da
Protein NamePeptidyl-prolyl cis-trans isomerase A
Human Gene Id5478
Human Swiss Prot NoP62937
Mouse Gene Id268373
Mouse Swiss Prot NoP17742
Rat Gene Id100360977
Rat Swiss Prot NoP10111
SpecificityCyPA Polyclonal Antibody detects endogenous levels of CyPA protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePPIA; CYPA; Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A
Observed Band(KD)18
Functioncatalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.,function:PPIases accelerate the folding of proteins.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,online information:Cyclophilin entry,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subunit:Interacts with HIV-1 Capsid protein.,
Subcellular LocationCytoplasm . Secreted . Nucleus . Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that includes Rho GTPase signaling, actin remodeling, and myosin II activation. .
ExpressionBlood,Bone marrow,Brain,Cajal-Retzius cell,Cervix,Colon,Epithelium,Fetal br
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PPIA. AA range:51-100
Gene NamePPIA
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundpeptidylprolyl isomerase A(PPIA) Homo sapiens This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75197-Conjugate. Price: $485 / Size: 100μl.
E20-75197-FITC$485 / 100μlE20-75197-Biotin$485 / 100μlE20-75197-HRP$485 / 100μlE20-75197-AP$485 / 100μlE20-75197-AF350$485 / 100μlE20-75197-AF405M$485 / 100μlE20-75197-AF488$485 / 100μlE20-75197-AF514$485 / 100μlE20-75197-AF532$485 / 100μlE20-75197-AF555$485 / 100μlE20-75197-AF568$485 / 100μlE20-75197-AF405S$485 / 100μlE20-75197-AF405L$485 / 100μlE20-75197-AF546$485 / 100μlE20-75197-AF594$485 / 100μlE20-75197-AF610$485 / 100μlE20-75197-AF635$485 / 100μlE20-75197-AF647$485 / 100μlE20-75197-AF680$485 / 100μlE20-75197-AF700$485 / 100μlE20-75197-AF750$485 / 100μlE20-75197-AF790$485 / 100μlE20-75197-APC$485 / 100μlE20-75197-PE$485 / 100μlE20-75197-Cy3$485 / 100μlE20-75197-Cy5$485 / 100μlE20-75197-Cy5.5$485 / 100μlE20-75197-Cy7$485 / 100μlE20-75197-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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