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Cell Signal Transduction Research Antibodies
Rock-2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight160913Da
Protein NameRho-associated protein kinase 2
Human Gene Id9475
Human Swiss Prot NoO75116
Mouse Gene Id19878
Mouse Swiss Prot NoP70336
Rat Gene Id25537
Rat Swiss Prot NoQ62868
SpecificityRock-2 Polyclonal Antibody detects endogenous levels of Rock-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameROCK2; KIAA0619; Rho-associated protein kinase 2; Rho kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; ROCK-II; p164 ROCK-2
Observed Band(KD)160
Functioncatalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by RHOA binding.,function:Protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton. Promotes formation of stress fibers and of focal adhesion complexes. Plays a role in smooth muscle contraction.,miscellaneous:Inhibited by Y-27632.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 REM (Hr1) repeat.,subcellular location:Cytoplasmic, and associated with actin microfilaments and the plasma membrane.,subunit:Homodim
Subcellular LocationCytoplasm. Cell membrane ; Peripheral membrane protein . Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic, and associated with actin microfilaments and the plasma membrane. .
ExpressionExpressed in the brain (at protein level).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ROCK2. AA range:1021-1070
Gene NameROCK2
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
BackgroundRho associated coiled-coil containing protein kinase 2(ROCK2) Homo sapiens The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75193-Conjugate. Price: $485 / Size: 100μl.
E20-75193-FITC$485 / 100μlE20-75193-Biotin$485 / 100μlE20-75193-HRP$485 / 100μlE20-75193-AP$485 / 100μlE20-75193-AF350$485 / 100μlE20-75193-AF405M$485 / 100μlE20-75193-AF488$485 / 100μlE20-75193-AF514$485 / 100μlE20-75193-AF532$485 / 100μlE20-75193-AF555$485 / 100μlE20-75193-AF568$485 / 100μlE20-75193-AF405S$485 / 100μlE20-75193-AF405L$485 / 100μlE20-75193-AF546$485 / 100μlE20-75193-AF594$485 / 100μlE20-75193-AF610$485 / 100μlE20-75193-AF635$485 / 100μlE20-75193-AF647$485 / 100μlE20-75193-AF680$485 / 100μlE20-75193-AF700$485 / 100μlE20-75193-AF750$485 / 100μlE20-75193-AF790$485 / 100μlE20-75193-APC$485 / 100μlE20-75193-PE$485 / 100μlE20-75193-Cy3$485 / 100μlE20-75193-Cy5$485 / 100μlE20-75193-Cy5.5$485 / 100μlE20-75193-Cy7$485 / 100μlE20-75193-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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