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Cell Signal Transduction Research Antibodies
CUL-4B Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight102299Da
Protein NameCullin-4B
Human Gene Id8450
Human Swiss Prot NoQ13620
Mouse Gene Id72584
Mouse Swiss Prot NoA2A432
SpecificityCUL-4B Polyclonal Antibody detects endogenous levels of CUL-4B protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCUL4B; KIAA0695; Cullin-4B; CUL-4B
Observed Band(KD)110
Functiondisease:Defects in CUL4B are the cause of Cabezas X-linked mental retardation syndrome (MRXC) [MIM:300354]; also called X-linked mental retardation with short stature small testes muscle wasting and tremor. MRXC patients show delayed puberty, hypogonadism, relative macrocephaly, moderate short stature, central obesity, unprovoked aggressive outbursts, fine intention tremor, pes cavus, and abnormalities of the toes.,disease:Defects in CUL4B are the cause of X-linked mental retardation-hypotonic facies syndrome type 2 (MRXHF2) [MIM:300639]; also called Smith-Fineman-Myers syndrome type 2 or SFM2. The distinguishing manifestations of MRXHF2 are relative microcephaly, short stature, hypertelorism, macrostomia, patulous lips, difficulty in speech, micrognathia, short thumbs and little fingers with adduction, hypotonia at age less than 10 years, and later hypertonia, restlessness, and seizures
Subcellular LocationNucleus .
ExpressionBrain,Fetal liver,Testis,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CUL4B. AA range:711-760
Gene NameCUL4B
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundcullin 4B(CUL4B) Homo sapiens This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75188-Conjugate. Price: $485 / Size: 100μl.
E20-75188-FITC$485 / 100μlE20-75188-Biotin$485 / 100μlE20-75188-HRP$485 / 100μlE20-75188-AP$485 / 100μlE20-75188-AF350$485 / 100μlE20-75188-AF405M$485 / 100μlE20-75188-AF488$485 / 100μlE20-75188-AF514$485 / 100μlE20-75188-AF532$485 / 100μlE20-75188-AF555$485 / 100μlE20-75188-AF568$485 / 100μlE20-75188-AF405S$485 / 100μlE20-75188-AF405L$485 / 100μlE20-75188-AF546$485 / 100μlE20-75188-AF594$485 / 100μlE20-75188-AF610$485 / 100μlE20-75188-AF635$485 / 100μlE20-75188-AF647$485 / 100μlE20-75188-AF680$485 / 100μlE20-75188-AF700$485 / 100μlE20-75188-AF750$485 / 100μlE20-75188-AF790$485 / 100μlE20-75188-APC$485 / 100μlE20-75188-PE$485 / 100μlE20-75188-Cy3$485 / 100μlE20-75188-Cy5$485 / 100μlE20-75188-Cy5.5$485 / 100μlE20-75188-Cy7$485 / 100μlE20-75188-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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