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Cell Signal Transduction Research Antibodies
p63 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight76785Da
Protein NameTumor protein 63
Human Gene Id8626
Human Swiss Prot NoQ9H3D4
Mouse Gene Id22061
Mouse Swiss Prot NoO88898
Rat Gene Id246334
Rat Swiss Prot NoQ9JJP6
Specificityp63 Polyclonal Antibody detects endogenous levels of p63 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTP63; KET; P63; P73H; P73L; TP73L; Tumor protein 63; p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51
Observed Band(KD)63
Functioncofactor:Binds 1 zinc ion per subunit.,disease:Defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers.,disease:Defects in TP63 are a cause of ectodermal dysplasia Rapp-Hodgkin type (EDRH) [MIM:129400]; also called Rapp-Hodgkin syndrome or anhidrotic ectodermal dysplasia with cleft lip/palate. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDRH is characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and
Subcellular LocationNucleus .
ExpressionWidely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human TP63. AA range:51-100
Gene NameTP63
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundtumor protein p63(TP63) Homo sapiens This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrim
Conjugated Antibody
This product is also available conjugated. Format: E20-75183-Conjugate. Price: $485 / Size: 100μl.
E20-75183-FITC$485 / 100μlE20-75183-Biotin$485 / 100μlE20-75183-HRP$485 / 100μlE20-75183-AP$485 / 100μlE20-75183-AF350$485 / 100μlE20-75183-AF405M$485 / 100μlE20-75183-AF488$485 / 100μlE20-75183-AF514$485 / 100μlE20-75183-AF532$485 / 100μlE20-75183-AF555$485 / 100μlE20-75183-AF568$485 / 100μlE20-75183-AF405S$485 / 100μlE20-75183-AF405L$485 / 100μlE20-75183-AF546$485 / 100μlE20-75183-AF594$485 / 100μlE20-75183-AF610$485 / 100μlE20-75183-AF635$485 / 100μlE20-75183-AF647$485 / 100μlE20-75183-AF680$485 / 100μlE20-75183-AF700$485 / 100μlE20-75183-AF750$485 / 100μlE20-75183-AF790$485 / 100μlE20-75183-APC$485 / 100μlE20-75183-PE$485 / 100μlE20-75183-Cy3$485 / 100μlE20-75183-Cy5$485 / 100μlE20-75183-Cy5.5$485 / 100μlE20-75183-Cy7$485 / 100μlE20-75183-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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