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Cell Signal Transduction Research Antibodies
ALK-1 Polyclonal Antibody
Polyclonal, RabbitDilution:Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight56124DaObserved Band:56 KD
Protein NameSerine/threonine-protein kinase receptor R3
Human Gene Id94
Human Swiss Prot NoP37023
Mouse Gene Id11482
Mouse Swiss Prot NoQ61288
Rat Gene Id25237
Rat Swiss Prot NoP80203
SpecificityALK-1 Polyclonal Antibody detects endogenous levels of ALK-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameACVRL1; ACVRLK1; ALK1; Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I
Functioncatalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.,simi
Subcellular Locationplasma membrane,integral component of plasma membrane,cell surface,membrane,integral component of membrane,dendrite,neuronal cell body,
ExpressionBrain,Placenta,,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human ACVRL1. AA range:21-70
Gene NameACVRL1
Backgroundactivin A receptor like type 1(ACVRL1) Homo sapiens This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75182-Conjugate. Price: $485 / Size: 100μl.
E20-75182-FITC$485 / 100μlE20-75182-Biotin$485 / 100μlE20-75182-HRP$485 / 100μlE20-75182-AP$485 / 100μlE20-75182-AF350$485 / 100μlE20-75182-AF405M$485 / 100μlE20-75182-AF488$485 / 100μlE20-75182-AF514$485 / 100μlE20-75182-AF532$485 / 100μlE20-75182-AF555$485 / 100μlE20-75182-AF568$485 / 100μlE20-75182-AF405S$485 / 100μlE20-75182-AF405L$485 / 100μlE20-75182-AF546$485 / 100μlE20-75182-AF594$485 / 100μlE20-75182-AF610$485 / 100μlE20-75182-AF635$485 / 100μlE20-75182-AF647$485 / 100μlE20-75182-AF680$485 / 100μlE20-75182-AF700$485 / 100μlE20-75182-AF750$485 / 100μlE20-75182-AF790$485 / 100μlE20-75182-APC$485 / 100μlE20-75182-PE$485 / 100μlE20-75182-Cy3$485 / 100μlE20-75182-Cy5$485 / 100μlE20-75182-Cy5.5$485 / 100μlE20-75182-Cy7$485 / 100μlE20-75182-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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