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Cell Signal Transduction Research Antibodies
Lamin B1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight66408DaObserved Band:70KD
Protein NameLamin-B1
Human Gene Id4001
Human Swiss Prot NoP20700
Mouse Gene Id16906
Mouse Swiss Prot NoP14733
Rat Gene Id116685
Rat Swiss Prot NoP70615
SpecificityLamin B1 Polyclonal Antibody detects endogenous levels of Lamin B1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameLMNB1; LMN2; LMNB; Lamin-B1
Functiondisease:Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.,function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle
Subcellular Locationnuclear envelope,nuclear inner membrane,lamin filament,nucleoplasm,membrane,nuclear matrix,nuclear membrane,
ExpressionBrain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Ovarian carcinoma,Placenta,Uterus,,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human LMNB1. AA range:391-440
Gene NameLMNB1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundlamin B1(LMNB1) Homo sapiens This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75180-Conjugate. Price: $485 / Size: 100μl.
E20-75180-FITC$485 / 100μlE20-75180-Biotin$485 / 100μlE20-75180-HRP$485 / 100μlE20-75180-AP$485 / 100μlE20-75180-AF350$485 / 100μlE20-75180-AF405M$485 / 100μlE20-75180-AF488$485 / 100μlE20-75180-AF514$485 / 100μlE20-75180-AF532$485 / 100μlE20-75180-AF555$485 / 100μlE20-75180-AF568$485 / 100μlE20-75180-AF405S$485 / 100μlE20-75180-AF405L$485 / 100μlE20-75180-AF546$485 / 100μlE20-75180-AF594$485 / 100μlE20-75180-AF610$485 / 100μlE20-75180-AF635$485 / 100μlE20-75180-AF647$485 / 100μlE20-75180-AF680$485 / 100μlE20-75180-AF700$485 / 100μlE20-75180-AF750$485 / 100μlE20-75180-AF790$485 / 100μlE20-75180-APC$485 / 100μlE20-75180-PE$485 / 100μlE20-75180-Cy3$485 / 100μlE20-75180-Cy5$485 / 100μlE20-75180-Cy5.5$485 / 100μlE20-75180-Cy7$485 / 100μlE20-75180-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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