World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
cPLA2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight85211DaObserved Band: 114KD
Protein NameCytosolic phospholipase A2
Human Gene Id5321
Human Swiss Prot NoP47712
Mouse Gene Id18783
Mouse Swiss Prot NoP47713
Rat Swiss Prot NoP50393
SpecificitycPLA2 Polyclonal Antibody detects endogenous levels of cPLA2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePLA2G4A; CPLA2; PLA2G4; Cytosolic phospholipase A2; cPLA2; Phospholipase A2 group IVA
Functioncatalytic activity:2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.,catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,domain:The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).,enzyme regulation:Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).,function:Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.,PTM:Activated by phosphorylation at both Ser-505 and Ser-727.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PLA2c domain.,subcellular location:Translocates to membrane ve
Subcellular Locationcytoplasm,mitochondrial inner membrane,endoplasmic reticulum membrane,Golgi apparatus,cytosol,cytoplasmic, membrane-bounded vesicle,cytoplasmic vesicle,
ExpressionEpithelium,Platelet,,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human PLA2G4A. AA range:31-80
Gene NamePLA2G4A
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundphospholipase A2 group IVA(PLA2G4A) Homo sapiens This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75176-Conjugate. Price: $485 / Size: 100μl.
E20-75176-FITC$485 / 100μlE20-75176-Biotin$485 / 100μlE20-75176-HRP$485 / 100μlE20-75176-AP$485 / 100μlE20-75176-AF350$485 / 100μlE20-75176-AF405M$485 / 100μlE20-75176-AF488$485 / 100μlE20-75176-AF514$485 / 100μlE20-75176-AF532$485 / 100μlE20-75176-AF555$485 / 100μlE20-75176-AF568$485 / 100μlE20-75176-AF405S$485 / 100μlE20-75176-AF405L$485 / 100μlE20-75176-AF546$485 / 100μlE20-75176-AF594$485 / 100μlE20-75176-AF610$485 / 100μlE20-75176-AF635$485 / 100μlE20-75176-AF647$485 / 100μlE20-75176-AF680$485 / 100μlE20-75176-AF700$485 / 100μlE20-75176-AF750$485 / 100μlE20-75176-AF790$485 / 100μlE20-75176-APC$485 / 100μlE20-75176-PE$485 / 100μlE20-75176-Cy3$485 / 100μlE20-75176-Cy5$485 / 100μlE20-75176-Cy5.5$485 / 100μlE20-75176-Cy7$485 / 100μlE20-75176-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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