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Cell Signal Transduction Research Antibodies
IL-16 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight66646DaObserved Band:66KD
Protein NamePro-interleukin-16
Human Gene Id3603
Human Swiss Prot NoQ14005
Mouse Swiss Prot NoO54824
SpecificityIL-16 Polyclonal Antibody detects endogenous levels of IL-16 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIL16; Pro-interleukin-16
Functionfunction:Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.,function:Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.,function:Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.,induction:Isoform 3 is down-regulated in T-cells after TCR activation.,PTM:Isoform 3 is synthesized as a chemo-attractant inacti
Subcellular Location[Interleukin-16]: Secreted.; [Isoform 1]: Cytoplasm .; [Isoform 3]: Cytoplasm. Nucleus.
Expression[Isoform 3]: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation.,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human IL-16. AA range:48-97
Gene NameIL16
DilutionImmunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Backgroundinterleukin 16(IL16) Homo sapiens The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-75175-Conjugate. Price: $485 / Size: 100μl.
E20-75175-FITC$485 / 100μlE20-75175-Biotin$485 / 100μlE20-75175-HRP$485 / 100μlE20-75175-AP$485 / 100μlE20-75175-AF350$485 / 100μlE20-75175-AF405M$485 / 100μlE20-75175-AF488$485 / 100μlE20-75175-AF514$485 / 100μlE20-75175-AF532$485 / 100μlE20-75175-AF555$485 / 100μlE20-75175-AF568$485 / 100μlE20-75175-AF405S$485 / 100μlE20-75175-AF405L$485 / 100μlE20-75175-AF546$485 / 100μlE20-75175-AF594$485 / 100μlE20-75175-AF610$485 / 100μlE20-75175-AF635$485 / 100μlE20-75175-AF647$485 / 100μlE20-75175-AF680$485 / 100μlE20-75175-AF700$485 / 100μlE20-75175-AF750$485 / 100μlE20-75175-AF790$485 / 100μlE20-75175-APC$485 / 100μlE20-75175-PE$485 / 100μlE20-75175-Cy3$485 / 100μlE20-75175-Cy5$485 / 100μlE20-75175-Cy5.5$485 / 100μlE20-75175-Cy7$485 / 100μlE20-75175-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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