World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Angptl4 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight45214DaObserved Band:45KD
Protein NameAngiopoietin-related protein 4
Human Gene Id51129
Human Swiss Prot NoQ9BY76
Mouse Gene Id57875
Mouse Swiss Prot NoQ9Z1P8
Rat Gene Id362850
Rat Swiss Prot NoQ6TMA8
SpecificityAngptl4 Polyclonal Antibody detects endogenous levels of Angptl4 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameANGPTL4; ARP4; HFARP; PGAR; PP1158; PSEC0166; Angiopoietin-related protein 4; Angiopoietin-like protein 4; Hepatic fibrinogen/angiopoietin-related protein; HFARP
Functioncaution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Found to be highly expressed in the early stages of collagen-induced arthritis (CIA).,disease:Produced in ischemic tissues in conditions such as critical leg ischemia. In tumors, ANGPTL4 could be produced in the hypoxic areas surrounding necrotic regions. High levels could be produced in tumor cells of conventional renal cell carcinoma. This molecule therefore seems to be a marker of conventional renal cell carcinoma.,disease:Serum levels of ANGPTL4 are significantly lower in patients with diabetes type 2 than those in healthy subjects, suggesting that decreased ANGPTL4 could be a causative factor of this disease.,function:Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis.
Subcellular LocationSecreted . Secreted, extracellular space, extracellular matrix . The unprocessed form interacts with the extracellular matrix (PubMed:17068295, PubMed:21398697). This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (Probable). .
ExpressionDetected in blood plasma (at protein level) (PubMed:29899519). Detected in liver (PubMed:10698685). Detected in white fat tissue and placenta (PubMed:10866690). Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney..
,
,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ANGPTL4. AA range:301-350
Gene NameANGPTL4
DilutionIHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundangiopoietin like 4(ANGPTL4) Homo sapiens This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013],
Conjugated Antibody
This product is also available conjugated. Format: E20-75174-Conjugate. Price: $485 / Size: 100μl.
E20-75174-FITC$485 / 100μlE20-75174-Biotin$485 / 100μlE20-75174-HRP$485 / 100μlE20-75174-AP$485 / 100μlE20-75174-AF350$485 / 100μlE20-75174-AF405M$485 / 100μlE20-75174-AF488$485 / 100μlE20-75174-AF514$485 / 100μlE20-75174-AF532$485 / 100μlE20-75174-AF555$485 / 100μlE20-75174-AF568$485 / 100μlE20-75174-AF405S$485 / 100μlE20-75174-AF405L$485 / 100μlE20-75174-AF546$485 / 100μlE20-75174-AF594$485 / 100μlE20-75174-AF610$485 / 100μlE20-75174-AF635$485 / 100μlE20-75174-AF647$485 / 100μlE20-75174-AF680$485 / 100μlE20-75174-AF700$485 / 100μlE20-75174-AF750$485 / 100μlE20-75174-AF790$485 / 100μlE20-75174-APC$485 / 100μlE20-75174-PE$485 / 100μlE20-75174-Cy3$485 / 100μlE20-75174-Cy5$485 / 100μlE20-75174-Cy5.5$485 / 100μlE20-75174-Cy7$485 / 100μlE20-75174-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits