World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Cytokeratin 14 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight51622Da
Protein NameKeratin type I cytoskeletal 14
Human Gene Id3861
Human Swiss Prot NoP02533
Mouse Gene Id16664
Mouse Swiss Prot NoQ61781
Rat Gene Id287701
Rat Swiss Prot NoQ6IFV1
SpecificityCytokeratin 14 Polyclonal Antibody detects endogenous levels of Cytokeratin 14 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameKRT14; Keratin; type I cytoskeletal 14; Cytokeratin-14; CK-14; Keratin-14; K14
Functiondisease:Defects in KRT14 are a cause of epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) [MIM:131760]. DM-EBS is a severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.,disease:Defects in KRT14 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS) [MIM:131900]. K-EBS is a form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, althought it is less severe.,disease:Defects in KRT14 are a cause of epidermolysis bullosa simplex Weber-Cockayne type (WC-EBS) [MIM:131800]. WC-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.,disease:Defects in KRT14 are the cause of derma
Subcellular LocationCytoplasm. Nucleus. Expressed in both as a filamentous pattern.
ExpressionExpressed in the corneal epithelium (at protein level) (PubMed:26758872). Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair (PubMed:9457912). Found in keratinocytes surrounding the club hair during telogen (PubMed:9457912).,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Cytokeratin 14. AA range:102-151
Gene NameKRT14
DilutionImmunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundkeratin 14(KRT14) Homo sapiens This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75173-Conjugate. Price: $485 / Size: 100μl.
E20-75173-FITC$485 / 100μlE20-75173-Biotin$485 / 100μlE20-75173-HRP$485 / 100μlE20-75173-AP$485 / 100μlE20-75173-AF350$485 / 100μlE20-75173-AF405M$485 / 100μlE20-75173-AF488$485 / 100μlE20-75173-AF514$485 / 100μlE20-75173-AF532$485 / 100μlE20-75173-AF555$485 / 100μlE20-75173-AF568$485 / 100μlE20-75173-AF405S$485 / 100μlE20-75173-AF405L$485 / 100μlE20-75173-AF546$485 / 100μlE20-75173-AF594$485 / 100μlE20-75173-AF610$485 / 100μlE20-75173-AF635$485 / 100μlE20-75173-AF647$485 / 100μlE20-75173-AF680$485 / 100μlE20-75173-AF700$485 / 100μlE20-75173-AF750$485 / 100μlE20-75173-AF790$485 / 100μlE20-75173-APC$485 / 100μlE20-75173-PE$485 / 100μlE20-75173-Cy3$485 / 100μlE20-75173-Cy5$485 / 100μlE20-75173-Cy5.5$485 / 100μlE20-75173-Cy7$485 / 100μlE20-75173-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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