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Cell Signal Transduction Research Antibodies
FGF-23 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight27954DaObserved Band:27KD
Protein NameFibroblast growth factor 23
Human Gene Id8074
Human Swiss Prot NoQ9GZV9
Mouse Gene Id64654
Mouse Swiss Prot NoQ9EPC2
Rat Gene Id170583
Rat Swiss Prot NoQ8VI82
SpecificityFGF-23 Polyclonal Antibody detects endogenous levels of FGF-23 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameFGF23; HYPF; Fibroblast growth factor 23; FGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor
Functiondisease:Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues.,disease:Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) [MIM:193100]. ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses.,PTM:After secretion it is processed into a N-terminal fragment and a C-terminal fragment. The processing is effected by the proprotein convertases.,similarity:Belongs to the heparin-binding growth factors family.,
Subcellular LocationSecreted . Secretion is dependent on O-glycosylation.
ExpressionExpressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts).,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human FGF23. AA range:151-200
Gene NameFGF23
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Backgroundfibroblast growth factor 23(FGF23) Homo sapiens This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013],
Conjugated Antibody
This product is also available conjugated. Format: E20-75171-Conjugate. Price: $485 / Size: 100μl.
E20-75171-FITC$485 / 100μlE20-75171-Biotin$485 / 100μlE20-75171-HRP$485 / 100μlE20-75171-AP$485 / 100μlE20-75171-AF350$485 / 100μlE20-75171-AF405M$485 / 100μlE20-75171-AF488$485 / 100μlE20-75171-AF514$485 / 100μlE20-75171-AF532$485 / 100μlE20-75171-AF555$485 / 100μlE20-75171-AF568$485 / 100μlE20-75171-AF405S$485 / 100μlE20-75171-AF405L$485 / 100μlE20-75171-AF546$485 / 100μlE20-75171-AF594$485 / 100μlE20-75171-AF610$485 / 100μlE20-75171-AF635$485 / 100μlE20-75171-AF647$485 / 100μlE20-75171-AF680$485 / 100μlE20-75171-AF700$485 / 100μlE20-75171-AF750$485 / 100μlE20-75171-AF790$485 / 100μlE20-75171-APC$485 / 100μlE20-75171-PE$485 / 100μlE20-75171-Cy3$485 / 100μlE20-75171-Cy5$485 / 100μlE20-75171-Cy5.5$485 / 100μlE20-75171-Cy7$485 / 100μlE20-75171-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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