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Cell Signal Transduction Research Antibodies
Trk C Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight94428DaObserved Band:95KD
Protein NameNT-3 growth factor receptor
Human Gene Id4916
Human Swiss Prot NoQ16288
Mouse Swiss Prot NoQ6VNS1
SpecificityTrk C Polyclonal Antibody detects endogenous levels of Trk C protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNTRK3; TRKC; NT-3 growth factor receptor; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase
Functionalternative products:Additional isoforms seem to exist,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.,PTM:Ligand-mediated auto-phosphorylation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 2 LRR (leucine-rich) repeats.,subunit:Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220.,tissue specificity:Widely expressed but mainly i
Subcellular LocationMembrane; Single-pass type I membrane protein.
ExpressionWidely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human NTRK3. AA range:281-330
Gene NameNTRK3
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundneurotrophic receptor tyrosine kinase 3(NTRK3) Homo sapiens This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75165-Conjugate. Price: $485 / Size: 100μl.
E20-75165-FITC$485 / 100μlE20-75165-Biotin$485 / 100μlE20-75165-HRP$485 / 100μlE20-75165-AP$485 / 100μlE20-75165-AF350$485 / 100μlE20-75165-AF405M$485 / 100μlE20-75165-AF488$485 / 100μlE20-75165-AF514$485 / 100μlE20-75165-AF532$485 / 100μlE20-75165-AF555$485 / 100μlE20-75165-AF568$485 / 100μlE20-75165-AF405S$485 / 100μlE20-75165-AF405L$485 / 100μlE20-75165-AF546$485 / 100μlE20-75165-AF594$485 / 100μlE20-75165-AF610$485 / 100μlE20-75165-AF635$485 / 100μlE20-75165-AF647$485 / 100μlE20-75165-AF680$485 / 100μlE20-75165-AF700$485 / 100μlE20-75165-AF750$485 / 100μlE20-75165-AF790$485 / 100μlE20-75165-APC$485 / 100μlE20-75165-PE$485 / 100μlE20-75165-Cy3$485 / 100μlE20-75165-Cy5$485 / 100μlE20-75165-Cy5.5$485 / 100μlE20-75165-Cy7$485 / 100μlE20-75165-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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