Product Information
Molecular Weight44868DaObserved Band:44KD
Protein NameDnaJ homolog subfamily A member 1
Human Gene Id3301
Human Swiss Prot NoP31689
Mouse Gene Id15502
Mouse Swiss Prot NoP63037
Rat Gene Id65028
Rat Swiss Prot NoP63036
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameDNAJA1; DNAJ2; HDJ2; HSJ2; HSPF4; DnaJ homolog subfamily A member 1; DnaJ protein homolog 2; HSDJ; Heat shock 40 kDa protein 4; Heat shock protein J2; HSJ-2; Human DnaJ protein 2; hDj-2
Functionfunction:Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria.,similarity:Contains 1 CR-type zinc finger.,similarity:Contains 1 J domain.,
Subcellular LocationMembrane ; Lipid-anchor . Cytoplasm . Microsome . Nucleus . Cytoplasm, perinuclear region . Mitochondrion . Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. .
ExpressionUbiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver.,
BackgroundDnaJ heat shock protein family (Hsp40) member A1(DNAJA1) Homo sapiens This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015],