Product Information
Molecular Weight26934DaObserved Band:13KD
Protein NameTissue factor pathway inhibitor 2
Human Gene Id7980
Human Swiss Prot NoP48307
Mouse Swiss Prot NoO35536
SpecificityTFPI-2 Polyclonal Antibody detects endogenous levels of TFPI-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTFPI2; Tissue factor pathway inhibitor 2; TFPI-2; Placental protein 5; PP5
Functiondomain:This inhibitor contains three inhibitory domains.,function:May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.,similarity:Contains 2 BPTI/Kunitz inhibitor domains.,similarity:Contains 3 BPTI/Kunitz inhibitor domains.,tissue specificity:Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.,
Subcellular LocationSecreted.
ExpressionUmbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.,
Backgroundtissue factor pathway inhibitor 2(TFPI2) Homo sapiens This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],