Product Information
Molecular Weight28461DaObserved Band:28KD
Protein NameBreast cancer metastasis-suppressor 1
Human Gene Id25855
Human Swiss Prot NoQ9HCU9
Mouse Gene Id107392
Mouse Swiss Prot NoQ99N20
Rat Gene Id100911841
Rat Swiss Prot NoQ5M7T3
SpecificityBRMS-1 Polyclonal Antibody detects endogenous levels of BRMS-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameBRMS1; Breast cancer metastasis-suppressor 1
Functionfunction:May be a mediator of metastasis suppression in breast carcinoma.,similarity:Belongs to the BRMS1 family.,tissue specificity:Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.,
Subcellular LocationNucleus. Cytoplasm. Predominantly nuclear.
ExpressionExpression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.,
Backgroundbreast cancer metastasis suppressor 1(BRMS1) Homo sapiens This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],