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Cell Signal Transduction Research Antibodies
c-FLIP Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight55344DaObserved Band:55KD
Protein NameCASP8 and FADD-like apoptosis regulator
Human Gene Id8837
Human Swiss Prot NoO15519
Mouse Swiss Prot NoO35732
Specificityc-FLIP Polyclonal Antibody detects endogenous levels of c-FLIP protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCFLAR; CASH; CASP8AP1; CLARP; MRIT; CASP8 and FADD-like apoptosis regulator; Caspase homolog; CASH; Caspase-eight-related protein; Casper; Caspase-like apoptosis regulatory protein; CLARP; Cellular FLICE-like inhibitory protein; c-FLIP; FAD
Functiondomain:The caspase domain lacks the active sites residues involved in catalysis.,function:Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.,induction:Repressed by IL-2 after TCR stimulation, during progression to the S-phase of the cell cycle.,PTM:Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.,similarity:Belongs to the peptidase C14A family.,similarity:Contains
Subcellular Locationcytoplasm,cytosol,death-inducing signaling complex,CD95 death-inducing signaling complex,membrane raft,ripoptosome,
ExpressionWidely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human CFLAR. AA range:181-230
Gene NameCFLAR
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundCASP8 and FADD like apoptosis regulator(CFLAR) Homo sapiens The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75156-Conjugate. Price: $485 / Size: 100μl.
E20-75156-FITC$485 / 100μlE20-75156-Biotin$485 / 100μlE20-75156-HRP$485 / 100μlE20-75156-AP$485 / 100μlE20-75156-AF350$485 / 100μlE20-75156-AF405M$485 / 100μlE20-75156-AF488$485 / 100μlE20-75156-AF514$485 / 100μlE20-75156-AF532$485 / 100μlE20-75156-AF555$485 / 100μlE20-75156-AF568$485 / 100μlE20-75156-AF405S$485 / 100μlE20-75156-AF405L$485 / 100μlE20-75156-AF546$485 / 100μlE20-75156-AF594$485 / 100μlE20-75156-AF610$485 / 100μlE20-75156-AF635$485 / 100μlE20-75156-AF647$485 / 100μlE20-75156-AF680$485 / 100μlE20-75156-AF700$485 / 100μlE20-75156-AF750$485 / 100μlE20-75156-AF790$485 / 100μlE20-75156-APC$485 / 100μlE20-75156-PE$485 / 100μlE20-75156-Cy3$485 / 100μlE20-75156-Cy5$485 / 100μlE20-75156-Cy5.5$485 / 100μlE20-75156-Cy7$485 / 100μlE20-75156-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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