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Cell Signal Transduction Research Antibodies
Hrs Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight86192DaObserved Band:85KD
Protein NameHepatocyte growth factor-regulated tyrosine kinase substrate
Human Gene Id9146
Human Swiss Prot NoO14964
Mouse Gene Id15239
Mouse Swiss Prot NoQ99LI8
Rat Gene Id56084
Rat Swiss Prot NoQ9JJ50
SpecificityHrs Polyclonal Antibody detects endogenous levels of Hrs protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameHGS; HRS; Hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Protein pp110
Functiondomain:Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix.,function:Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the
Subcellular LocationCytoplasm . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome, multivesicular body membrane ; Peripheral membrane protein . Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments. .
ExpressionUbiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human HGS. AA range:511-560
Gene NameHGS
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundhepatocyte growth factor-regulated tyrosine kinase substrate(HGS) Homo sapiens The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-75152-Conjugate. Price: $485 / Size: 100μl.
E20-75152-FITC$485 / 100μlE20-75152-Biotin$485 / 100μlE20-75152-HRP$485 / 100μlE20-75152-AP$485 / 100μlE20-75152-AF350$485 / 100μlE20-75152-AF405M$485 / 100μlE20-75152-AF488$485 / 100μlE20-75152-AF514$485 / 100μlE20-75152-AF532$485 / 100μlE20-75152-AF555$485 / 100μlE20-75152-AF568$485 / 100μlE20-75152-AF405S$485 / 100μlE20-75152-AF405L$485 / 100μlE20-75152-AF546$485 / 100μlE20-75152-AF594$485 / 100μlE20-75152-AF610$485 / 100μlE20-75152-AF635$485 / 100μlE20-75152-AF647$485 / 100μlE20-75152-AF680$485 / 100μlE20-75152-AF700$485 / 100μlE20-75152-AF750$485 / 100μlE20-75152-AF790$485 / 100μlE20-75152-APC$485 / 100μlE20-75152-PE$485 / 100μlE20-75152-Cy3$485 / 100μlE20-75152-Cy5$485 / 100μlE20-75152-Cy5.5$485 / 100μlE20-75152-Cy7$485 / 100μlE20-75152-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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