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Cell Signal Transduction Research Antibodies
TNF-α Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight25644DaObserved Band:16KD
Protein NameTumor necrosis factor
Human Gene Id7124
Human Swiss Prot NoP01375
Mouse Gene Id21926
Mouse Swiss Prot NoP06804
Rat Gene Id24835
Rat Swiss Prot NoP16599
SpecificityTNF-α Polyclonal Antibody detects endogenous levels of TNF-α protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTNF; TNFA; TNFSF2; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a
Functiondisease:Cachexia accompanies a variety of diseases, including cancer and infection, and is characterized by general ill health and malnutrition.,disease:Genetic variations in TNF are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,disease:Genetic variations in TNF are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated w
Subcellular LocationCell membrane ; Single-pass type II membrane protein .; [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein.; [Tumor necrosis factor, soluble form]: Secreted .; [C-domain 1]: Secreted.; [C-domain 2]: Secreted.
ExpressionBlood,Peripheral blood leukocyte,Placenta,Prostatic carcinoma,,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human TNFA. AA range:141-190
Gene NameTNF
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Backgroundtumor necrosis factor(TNF) Homo sapiens This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75151-Conjugate. Price: $485 / Size: 100μl.
E20-75151-FITC$485 / 100μlE20-75151-Biotin$485 / 100μlE20-75151-HRP$485 / 100μlE20-75151-AP$485 / 100μlE20-75151-AF350$485 / 100μlE20-75151-AF405M$485 / 100μlE20-75151-AF488$485 / 100μlE20-75151-AF514$485 / 100μlE20-75151-AF532$485 / 100μlE20-75151-AF555$485 / 100μlE20-75151-AF568$485 / 100μlE20-75151-AF405S$485 / 100μlE20-75151-AF405L$485 / 100μlE20-75151-AF546$485 / 100μlE20-75151-AF594$485 / 100μlE20-75151-AF610$485 / 100μlE20-75151-AF635$485 / 100μlE20-75151-AF647$485 / 100μlE20-75151-AF680$485 / 100μlE20-75151-AF700$485 / 100μlE20-75151-AF750$485 / 100μlE20-75151-AF790$485 / 100μlE20-75151-APC$485 / 100μlE20-75151-PE$485 / 100μlE20-75151-Cy3$485 / 100μlE20-75151-Cy5$485 / 100μlE20-75151-Cy5.5$485 / 100μlE20-75151-Cy7$485 / 100μlE20-75151-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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