World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
PKC γ Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight78448DaObserved Band:78KD
Protein NameProtein kinase C gamma type
Human Gene Id5582
Human Swiss Prot NoP05129
Mouse Gene Id18752
Mouse Swiss Prot NoP63318
Rat Gene Id24681
Rat Swiss Prot NoP63319
SpecificityPKC γ Polyclonal Antibody detects endogenous levels of PKC γ protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePRKCG; PKCG; Protein kinase C gamma type; PKC-gamma
Functioncatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domain.,disease:Defects in PRKCG are the cause of spinocerebellar ataxia type 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA14 is an autosomal dominant cerebellar ataxia (ADCA).,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.,function:This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.,online infor
Subcellular LocationCytoplasm . Cytoplasm, perinuclear region . Cell membrane ; Peripheral membrane protein . Cell junction, synapse, synaptosome . Cell projection, dendrite . Translocates to synaptic membranes on stimulation. .
ExpressionExpressed in Purkinje cells of the cerebellar cortex.,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PRKCG. AA range:521-570
Gene NamePRKCG
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundprotein kinase C gamma(PRKCG) Homo sapiens Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neurop
Conjugated Antibody
This product is also available conjugated. Format: E20-75148-Conjugate. Price: $485 / Size: 100μl.
E20-75148-FITC$485 / 100μlE20-75148-Biotin$485 / 100μlE20-75148-HRP$485 / 100μlE20-75148-AP$485 / 100μlE20-75148-AF350$485 / 100μlE20-75148-AF405M$485 / 100μlE20-75148-AF488$485 / 100μlE20-75148-AF514$485 / 100μlE20-75148-AF532$485 / 100μlE20-75148-AF555$485 / 100μlE20-75148-AF568$485 / 100μlE20-75148-AF405S$485 / 100μlE20-75148-AF405L$485 / 100μlE20-75148-AF546$485 / 100μlE20-75148-AF594$485 / 100μlE20-75148-AF610$485 / 100μlE20-75148-AF635$485 / 100μlE20-75148-AF647$485 / 100μlE20-75148-AF680$485 / 100μlE20-75148-AF700$485 / 100μlE20-75148-AF750$485 / 100μlE20-75148-AF790$485 / 100μlE20-75148-APC$485 / 100μlE20-75148-PE$485 / 100μlE20-75148-Cy3$485 / 100μlE20-75148-Cy5$485 / 100μlE20-75148-Cy5.5$485 / 100μlE20-75148-Cy7$485 / 100μlE20-75148-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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