Product Information
Molecular Weight24425DaObserved Band:25KD
Protein NameEndothelin-1
Human Gene Id1906
Human Swiss Prot NoP05305
Mouse Swiss Prot NoP22387
SpecificityET-1 Polyclonal Antibody detects endogenous levels of ET-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameEDN1; Endothelin-1; Preproendothelin-1; PPET1
Functionfunction:Endothelins are endothelium-derived vasoconstrictor peptides.,online information:Endothelin entry,similarity:Belongs to the endothelin/sarafotoxin family.,tissue specificity:Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.,
Subcellular LocationSecreted.
ExpressionExpressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.,
Backgroundendothelin 1(EDN1) Homo sapiens This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],