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Cell Signal Transduction Research Antibodies
LXRα Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight50396DaObserved Band:50KD
Protein NameOxysterols receptor LXR-alpha
Human Gene Id10062
Human Swiss Prot NoQ13133
Mouse Gene Id22259
Mouse Swiss Prot NoQ9Z0Y9
Rat Swiss Prot NoQ62685
SpecificityLXRα Polyclonal Antibody detects endogenous levels of LXRα protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNR1H3; LXRA; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3
Functionfunction:Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis.,induction:By 9-cis retinoic acid (9CRA).,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Heterodimer of LXRA and RXR.,tissue specificity:Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.,
Subcellular LocationNucleus . Cytoplasm .
ExpressionVisceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human NR1H3. AA range:151-200
Gene NameNR1H3
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundnuclear receptor subfamily 1 group H member 3(NR1H3) Homo sapiens The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75143-Conjugate. Price: $485 / Size: 100μl.
E20-75143-FITC$485 / 100μlE20-75143-Biotin$485 / 100μlE20-75143-HRP$485 / 100μlE20-75143-AP$485 / 100μlE20-75143-AF350$485 / 100μlE20-75143-AF405M$485 / 100μlE20-75143-AF488$485 / 100μlE20-75143-AF514$485 / 100μlE20-75143-AF532$485 / 100μlE20-75143-AF555$485 / 100μlE20-75143-AF568$485 / 100μlE20-75143-AF405S$485 / 100μlE20-75143-AF405L$485 / 100μlE20-75143-AF546$485 / 100μlE20-75143-AF594$485 / 100μlE20-75143-AF610$485 / 100μlE20-75143-AF635$485 / 100μlE20-75143-AF647$485 / 100μlE20-75143-AF680$485 / 100μlE20-75143-AF700$485 / 100μlE20-75143-AF750$485 / 100μlE20-75143-AF790$485 / 100μlE20-75143-APC$485 / 100μlE20-75143-PE$485 / 100μlE20-75143-Cy3$485 / 100μlE20-75143-Cy5$485 / 100μlE20-75143-Cy5.5$485 / 100μlE20-75143-Cy7$485 / 100μlE20-75143-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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