World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
MMP-12 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight54002DaObserved Band:48KD
Protein NameMacrophage metalloelastase
Human Gene Id4321
Human Swiss Prot NoP39900
Mouse Swiss Prot NoP34960
SpecificityMMP-12 Polyclonal Antibody detects endogenous levels of MMP-12 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMMP12; HME; Macrophage metalloelastase; MME; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12
Functioncatalytic activity:Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.,induction:By exposure to lipopolysaccharide. Inhibited by dexamethasone.,similarity:Belongs to the p
Subcellular LocationSecreted, extracellular space, extracellular matrix .
ExpressionFound in alveolar macrophages but not in peripheral blood monocytes.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human MMP-12. AA range:362-411
Gene NameMMP12
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Backgroundmatrix metallopeptidase 12(MMP12) Homo sapiens This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-75137-Conjugate. Price: $485 / Size: 100μl.
E20-75137-FITC$485 / 100μlE20-75137-Biotin$485 / 100μlE20-75137-HRP$485 / 100μlE20-75137-AP$485 / 100μlE20-75137-AF350$485 / 100μlE20-75137-AF405M$485 / 100μlE20-75137-AF488$485 / 100μlE20-75137-AF514$485 / 100μlE20-75137-AF532$485 / 100μlE20-75137-AF555$485 / 100μlE20-75137-AF568$485 / 100μlE20-75137-AF405S$485 / 100μlE20-75137-AF405L$485 / 100μlE20-75137-AF546$485 / 100μlE20-75137-AF594$485 / 100μlE20-75137-AF610$485 / 100μlE20-75137-AF635$485 / 100μlE20-75137-AF647$485 / 100μlE20-75137-AF680$485 / 100μlE20-75137-AF700$485 / 100μlE20-75137-AF750$485 / 100μlE20-75137-AF790$485 / 100μlE20-75137-APC$485 / 100μlE20-75137-PE$485 / 100μlE20-75137-Cy3$485 / 100μlE20-75137-Cy5$485 / 100μlE20-75137-Cy5.5$485 / 100μlE20-75137-Cy7$485 / 100μlE20-75137-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits