Product Information
Molecular Weight24603DaObserved Band:24KD
Protein NameClaudin-17
Human Gene Id26285
Human Swiss Prot NoP56750
Mouse Gene Id239931
Mouse Swiss Prot NoQ8BXA6
SpecificityClaudin-17 Polyclonal Antibody detects endogenous levels of Claudin-17 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCLDN17; Claudin-17
Functionfunction:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,
Subcellular LocationCell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
ExpressionIn the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).
Backgroundclaudin 17(CLDN17) Homo sapiens This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010],