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Cell Signal Transduction Research Antibodies
DR3 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight45385DaObserved Band:45KD
Protein NameTumor necrosis factor receptor superfamily member 25
Human Gene Id8718
Human Swiss Prot NoQ93038
SpecificityDR3 Polyclonal Antibody detects endogenous levels of DR3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTNFRSF25; APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; Tumor necrosis factor receptor superfamily member 25; Apo-3; Apoptosis-inducing receptor AIR;Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; Death receptor 3; Lymphocyte-associated receptor of death; LARD; Protein WSL; Protein WSL-1
Functionfunction:Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.,PTM:Glycosylated.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.,tissue specificity:Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.,
Subcellular Location[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 9]: Cell membrane; Single-pass type I membrane protein.; [Isoform 11]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; [Isoform 8]: Secreted.; [Isoform 10]: Secreted.; [Isoform 12]: Secreted.
ExpressionAbundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from DR3 . at AA range: 230-310
Gene NameTNFRSF25
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
BackgroundTNF receptor superfamily member 25(TNFRSF25) Homo sapiens The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involve
Conjugated Antibody
This product is also available conjugated. Format: E20-75135-Conjugate. Price: $485 / Size: 100μl.
E20-75135-FITC$485 / 100μlE20-75135-Biotin$485 / 100μlE20-75135-HRP$485 / 100μlE20-75135-AP$485 / 100μlE20-75135-AF350$485 / 100μlE20-75135-AF405M$485 / 100μlE20-75135-AF488$485 / 100μlE20-75135-AF514$485 / 100μlE20-75135-AF532$485 / 100μlE20-75135-AF555$485 / 100μlE20-75135-AF568$485 / 100μlE20-75135-AF405S$485 / 100μlE20-75135-AF405L$485 / 100μlE20-75135-AF546$485 / 100μlE20-75135-AF594$485 / 100μlE20-75135-AF610$485 / 100μlE20-75135-AF635$485 / 100μlE20-75135-AF647$485 / 100μlE20-75135-AF680$485 / 100μlE20-75135-AF700$485 / 100μlE20-75135-AF750$485 / 100μlE20-75135-AF790$485 / 100μlE20-75135-APC$485 / 100μlE20-75135-PE$485 / 100μlE20-75135-Cy3$485 / 100μlE20-75135-Cy5$485 / 100μlE20-75135-Cy5.5$485 / 100μlE20-75135-Cy7$485 / 100μlE20-75135-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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