Prothrombin Polyclonal Antibody

Name: Prothrombin Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75126
Price: 225 USD
Availability: InStock

E20-75126Cite ID: EN0055259Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight(Da):70037

Protein NameProthrombin

Human Gene Id2147

Human Swiss Prot NoP00734

Mouse Gene Id14061

Mouse Swiss Prot NoP19221

Rat Swiss Prot NoP18292

SpecificityProthrombin Polyclonal Antibody detects endogenous levels of Prothrombin protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameF2; Prothrombin; Coagulation factor II

Observed Band(KD)70

Functioncatalytic activity:Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.,disease:Defects in F2 are the cause of various forms of dysprothrombinemia [MIM:176930].,disease:Genetic variations in F2 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protei

Subcellular LocationSecreted, extracellular space.

ExpressionExpressed by the liver and secreted in plasma.,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from the Internal region of human Prothrombin.

Gene NameF2

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Backgroundcoagulation factor II, thrombin(F2) Homo sapiens Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75126-Conjugate. Price: $485 / Size: 100μl.

E20-75126-FITC$485 / 100μlE20-75126-Biotin$485 / 100μlE20-75126-HRP$485 / 100μlE20-75126-AP$485 / 100μlE20-75126-AF350$485 / 100μlE20-75126-AF405M$485 / 100μlE20-75126-AF488$485 / 100μlE20-75126-AF514$485 / 100μlE20-75126-AF532$485 / 100μlE20-75126-AF555$485 / 100μlE20-75126-AF568$485 / 100μlE20-75126-AF405S$485 / 100μlE20-75126-AF405L$485 / 100μlE20-75126-AF546$485 / 100μlE20-75126-AF594$485 / 100μlE20-75126-AF610$485 / 100μlE20-75126-AF635$485 / 100μlE20-75126-AF647$485 / 100μlE20-75126-AF680$485 / 100μlE20-75126-AF700$485 / 100μlE20-75126-AF750$485 / 100μlE20-75126-AF790$485 / 100μlE20-75126-APC$485 / 100μlE20-75126-PE$485 / 100μlE20-75126-Cy3$485 / 100μlE20-75126-Cy5$485 / 100μlE20-75126-Cy5.5$485 / 100μlE20-75126-Cy7$485 / 100μlE20-75126-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.