World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Cathepsin L Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight37564DaObserved Band:37KD
Protein NameCathepsin L1
Human Gene Id1514
Human Swiss Prot NoP07711
Mouse Swiss Prot NoP06797
SpecificityCathepsin L Polyclonal Antibody detects endogenous levels of Cathepsin L protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCTSL1; CTSL; Cathepsin L1; Major excreted protein; MEP
Functioncatalytic activity:Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.,function:Important for the overall degradation of proteins in lysosomes.,similarity:Belongs to the peptidase C1 family.,subunit:Dimer of a heavy and a light chain linked by disulfide bonds.,
Subcellular LocationLysosome . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted, extracellular space . Secreted . Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. .; [Isoform 2]: Nucleus . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520). Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520). .
ExpressionCartilage,Colon endothelium,Liver,Plasma,Prostate
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human Cathepsin L.
Gene NameCTSL1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundcathepsin L(CTSL) Homo sapiens The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012],
Conjugated Antibody
This product is also available conjugated. Format: E20-75124-Conjugate. Price: $485 / Size: 100μl.
E20-75124-FITC$485 / 100μlE20-75124-Biotin$485 / 100μlE20-75124-HRP$485 / 100μlE20-75124-AP$485 / 100μlE20-75124-AF350$485 / 100μlE20-75124-AF405M$485 / 100μlE20-75124-AF488$485 / 100μlE20-75124-AF514$485 / 100μlE20-75124-AF532$485 / 100μlE20-75124-AF555$485 / 100μlE20-75124-AF568$485 / 100μlE20-75124-AF405S$485 / 100μlE20-75124-AF405L$485 / 100μlE20-75124-AF546$485 / 100μlE20-75124-AF594$485 / 100μlE20-75124-AF610$485 / 100μlE20-75124-AF635$485 / 100μlE20-75124-AF647$485 / 100μlE20-75124-AF680$485 / 100μlE20-75124-AF700$485 / 100μlE20-75124-AF750$485 / 100μlE20-75124-AF790$485 / 100μlE20-75124-APC$485 / 100μlE20-75124-PE$485 / 100μlE20-75124-Cy3$485 / 100μlE20-75124-Cy5$485 / 100μlE20-75124-Cy5.5$485 / 100μlE20-75124-Cy7$485 / 100μlE20-75124-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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