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Cell Signal Transduction Research Antibodies
Contactin 1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight(Da):113320
Protein NameContactin-1
Human Gene Id1272
Human Swiss Prot NoQ12860
Mouse Gene Id12805
Mouse Swiss Prot NoP12960
Rat Gene Id117258
Rat Swiss Prot NoQ63198
SpecificityContactin 1 Polyclonal Antibody detects endogenous levels of Contactin 1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCNTN1; Contactin-1; Glycoprotein gp135; Neural cell surface protein F3
Observed Band(KD)113
Functiondisease:Defects in CNTN1 are the cause of Compton-North congenital myopathy [MIM:612540]. Compton-North congenital myopathy is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia.,function:Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucl
Subcellular Location[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
ExpressionStrongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the N-terminal region of human Contactin 1.
Gene NameCNTN1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundcontactin 1(CNTN1) Homo sapiens The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75122-Conjugate. Price: $485 / Size: 100μl.
E20-75122-FITC$485 / 100μlE20-75122-Biotin$485 / 100μlE20-75122-HRP$485 / 100μlE20-75122-AP$485 / 100μlE20-75122-AF350$485 / 100μlE20-75122-AF405M$485 / 100μlE20-75122-AF488$485 / 100μlE20-75122-AF514$485 / 100μlE20-75122-AF532$485 / 100μlE20-75122-AF555$485 / 100μlE20-75122-AF568$485 / 100μlE20-75122-AF405S$485 / 100μlE20-75122-AF405L$485 / 100μlE20-75122-AF546$485 / 100μlE20-75122-AF594$485 / 100μlE20-75122-AF610$485 / 100μlE20-75122-AF635$485 / 100μlE20-75122-AF647$485 / 100μlE20-75122-AF680$485 / 100μlE20-75122-AF700$485 / 100μlE20-75122-AF750$485 / 100μlE20-75122-AF790$485 / 100μlE20-75122-APC$485 / 100μlE20-75122-PE$485 / 100μlE20-75122-Cy3$485 / 100μlE20-75122-Cy5$485 / 100μlE20-75122-Cy5.5$485 / 100μlE20-75122-Cy7$485 / 100μlE20-75122-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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