Product Information
Molecular Weight44240DaObserved Band:44KD
Protein NameKrueppel-like factor 12
Human Gene Id11278
Human Swiss Prot NoQ9Y4X4
Mouse Gene Id16597
Mouse Swiss Prot NoO35738
SpecificityKLF12 Polyclonal Antibody detects endogenous levels of KLF12 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameKLF12; AP2REP; HSPC122; Krueppel-like factor 12; Transcriptional repressor AP-2rep
Functionfunction:Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,
Subcellular LocationNucleus.
ExpressionBrain,Hypothalamus,Umbilical cord blood,,
BackgroundKruppel like factor 12(KLF12) Homo sapiens Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],