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Cell Signal Transduction Research Antibodies
NFκB-p105 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight105356DaObserved Band:105KD
Protein NameNuclear factor NF-kappa-B p105 subunit
Human Gene Id4790
Human Swiss Prot NoP19838
Mouse Swiss Prot NoP25799
SpecificityNFκB-p105 Polyclonal Antibody detects endogenous levels of NFκB-p105 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Functiondomain:Glycine-rich region (GRR) appears to be a critical element in the generation of p50.,domain:The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation.,function:NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Diff
Subcellular LocationNucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
ExpressionMuscle,Rectum tumor,Uterus,,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human NF-kappaB p105/p50. AA range:874-923
Gene NameNFKB1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/10000. Not yet tested in other applications.
Backgroundnuclear factor kappa B subunit 1(NFKB1) Homo sapiens This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof
Conjugated Antibody
This product is also available conjugated. Format: E20-75109-Conjugate. Price: $485 / Size: 100μl.
E20-75109-FITC$485 / 100μlE20-75109-Biotin$485 / 100μlE20-75109-HRP$485 / 100μlE20-75109-AP$485 / 100μlE20-75109-AF350$485 / 100μlE20-75109-AF405M$485 / 100μlE20-75109-AF488$485 / 100μlE20-75109-AF514$485 / 100μlE20-75109-AF532$485 / 100μlE20-75109-AF555$485 / 100μlE20-75109-AF568$485 / 100μlE20-75109-AF405S$485 / 100μlE20-75109-AF405L$485 / 100μlE20-75109-AF546$485 / 100μlE20-75109-AF594$485 / 100μlE20-75109-AF610$485 / 100μlE20-75109-AF635$485 / 100μlE20-75109-AF647$485 / 100μlE20-75109-AF680$485 / 100μlE20-75109-AF700$485 / 100μlE20-75109-AF750$485 / 100μlE20-75109-AF790$485 / 100μlE20-75109-APC$485 / 100μlE20-75109-PE$485 / 100μlE20-75109-Cy3$485 / 100μlE20-75109-Cy5$485 / 100μlE20-75109-Cy5.5$485 / 100μlE20-75109-Cy7$485 / 100μlE20-75109-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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