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Cell Signal Transduction Research Antibodies
VEGF-A Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight27042Da
Protein Nameascular endothelial growth factor A
Human Swiss Prot NoP15692
Mouse Gene Id22339
Mouse Swiss Prot NoQ00731
Rat Gene Id83785
Rat Swiss Prot NoP16612
SpecificityVEGF-A Polyclonal Antibody detects endogenous levels of VEGF-A protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameVEGFA; VEGF; Vascular endothelial growth factor A; VEGF-A; Vascular permeability factor; VPF
Functionfunction:Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to VEGFR2/Kdr but doesn't activate downstream signaling pathways, doesn't activate angiogenesis and inhibits tumor growth.,induction:Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia and oncogenic mutations.,online information:VEGF entry,similarity:Belongs to the PDGF/VEGF growth factor family.,subcellular location:VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is f
Subcellular LocationSecreted . VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
ExpressionIsoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human VEGF-A. AA range:110-159
Gene NameVEGFA
DilutionIF: 1:50-200 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundvascular endothelial growth factor A(VEGFA) Homo sapiens This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation fro
Conjugated Antibody
This product is also available conjugated. Format: E20-75108-Conjugate. Price: $485 / Size: 100μl.
E20-75108-FITC$485 / 100μlE20-75108-Biotin$485 / 100μlE20-75108-HRP$485 / 100μlE20-75108-AP$485 / 100μlE20-75108-AF350$485 / 100μlE20-75108-AF405M$485 / 100μlE20-75108-AF488$485 / 100μlE20-75108-AF514$485 / 100μlE20-75108-AF532$485 / 100μlE20-75108-AF555$485 / 100μlE20-75108-AF568$485 / 100μlE20-75108-AF405S$485 / 100μlE20-75108-AF405L$485 / 100μlE20-75108-AF546$485 / 100μlE20-75108-AF594$485 / 100μlE20-75108-AF610$485 / 100μlE20-75108-AF635$485 / 100μlE20-75108-AF647$485 / 100μlE20-75108-AF680$485 / 100μlE20-75108-AF700$485 / 100μlE20-75108-AF750$485 / 100μlE20-75108-AF790$485 / 100μlE20-75108-APC$485 / 100μlE20-75108-PE$485 / 100μlE20-75108-Cy3$485 / 100μlE20-75108-Cy5$485 / 100μlE20-75108-Cy5.5$485 / 100μlE20-75108-Cy7$485 / 100μlE20-75108-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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