Product Information
Molecular Weight90636Da
Protein NameTransient receptor potential cation channel subfamily V member 3
Human Gene Id162514
Human Swiss Prot NoQ8NET8
Mouse Gene Id246788
Mouse Swiss Prot NoQ8K424
SpecificityTRPV3 Polyclonal Antibody detects endogenous levels of TRPV3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTRPV3; Transient receptor potential cation channel subfamily V member 3; TrpV3; Vanilloid receptor-like 3; VRL-3
Observed Band(KD)90
Functionfunction:Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 3 ANK repeats.,subunit:May form a heteromeric channel with TRPV1. Interacts with TRPV1.,tissue specificity:Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level).,
Subcellular Locationplasma membrane,integral component of plasma membrane,integral component of membrane,receptor complex,
ExpressionColon,Spleen,
Backgroundtransient receptor potential cation channel subfamily V member 3(TRPV3) Homo sapiens This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],