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Cell Signal Transduction Research Antibodies
IL-31Rα Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight82954Da
Protein NameInterleukin-31 receptor subunit alpha
Human Gene Id133396
Human Swiss Prot NoQ8NI17
Mouse Swiss Prot NoQ8K5B1
SpecificityIL-31Rα Polyclonal Antibody detects endogenous levels of IL-31Rα protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIL31RA; CRL3; GPL; Interleukin-31 receptor subunit alpha; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; Cytokine receptor-like 3; GLM-R; hGLM-R; Gp130-like monocyte receptor; Gp130-like receptor; ZcytoR17
Observed Band(KD)82
Functionfunction:Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity.,induction:Up-regulated in lesional keratinocytes of patients with atopic dermatitis. Up-regulated by IFNG and lipopolysaccharides.,PTM:N-glycosylated.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 5 fibronectin type-III domains.,subunit:Heterodimer with OSMR. Interacts with JAK1 and STAT3.,tissue specificity:Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14-and CD56-positive blood cells and by macrophages (at protein level).,
Subcellular Locationintracellular,plasma membrane,external side of plasma membrane,integral component of membrane,cell junction,axon,presynaptic membrane,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human IL-31Rα.
Gene NameIL31RA
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Backgroundinterleukin 31 receptor A(IL31RA) Homo sapiens The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75091-Conjugate. Price: $485 / Size: 100μl.
E20-75091-FITC$485 / 100μlE20-75091-Biotin$485 / 100μlE20-75091-HRP$485 / 100μlE20-75091-AP$485 / 100μlE20-75091-AF350$485 / 100μlE20-75091-AF405M$485 / 100μlE20-75091-AF488$485 / 100μlE20-75091-AF514$485 / 100μlE20-75091-AF532$485 / 100μlE20-75091-AF555$485 / 100μlE20-75091-AF568$485 / 100μlE20-75091-AF405S$485 / 100μlE20-75091-AF405L$485 / 100μlE20-75091-AF546$485 / 100μlE20-75091-AF594$485 / 100μlE20-75091-AF610$485 / 100μlE20-75091-AF635$485 / 100μlE20-75091-AF647$485 / 100μlE20-75091-AF680$485 / 100μlE20-75091-AF700$485 / 100μlE20-75091-AF750$485 / 100μlE20-75091-AF790$485 / 100μlE20-75091-APC$485 / 100μlE20-75091-PE$485 / 100μlE20-75091-Cy3$485 / 100μlE20-75091-Cy5$485 / 100μlE20-75091-Cy5.5$485 / 100μlE20-75091-Cy7$485 / 100μlE20-75091-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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