World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
NPRL2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight43658Da
Protein NameNitrogen permease regulator 2-like protein
Human Gene Id10641
Human Swiss Prot NoQ8WTW4
Mouse Gene Id56032
Mouse Swiss Prot NoQ9WUE4
SpecificityNPRL2 Polyclonal Antibody detects endogenous levels of NPRL2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNPRL2; TUSC4; Nitrogen permease regulator 2-like protein; NPR2-like protein; Gene 21 protein; G21 protein; Tumor suppressor candidate 4
Observed Band(KD)43
Functionfunction:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.,similarity:Belongs to the NPR2 family.,subunit:Interacts with PDPK1.,tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.,
Subcellular LocationLysosome membrane . Localization to lysosomes is amino acid-independent. .
ExpressionMost abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes (PubMed:27173016, PubMed:26505888). Expressed in most lung cancer cell lines tested.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the C-terminal region of human NPRL2.
Gene NameNPRL2
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundfunction:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.,similarity:Belongs to the NPR2 family.,subunit:Interacts with PDPK1.,tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.,
Conjugated Antibody
This product is also available conjugated. Format: E20-75086-Conjugate. Price: $485 / Size: 100μl.
E20-75086-FITC$485 / 100μlE20-75086-Biotin$485 / 100μlE20-75086-HRP$485 / 100μlE20-75086-AP$485 / 100μlE20-75086-AF350$485 / 100μlE20-75086-AF405M$485 / 100μlE20-75086-AF488$485 / 100μlE20-75086-AF514$485 / 100μlE20-75086-AF532$485 / 100μlE20-75086-AF555$485 / 100μlE20-75086-AF568$485 / 100μlE20-75086-AF405S$485 / 100μlE20-75086-AF405L$485 / 100μlE20-75086-AF546$485 / 100μlE20-75086-AF594$485 / 100μlE20-75086-AF610$485 / 100μlE20-75086-AF635$485 / 100μlE20-75086-AF647$485 / 100μlE20-75086-AF680$485 / 100μlE20-75086-AF700$485 / 100μlE20-75086-AF750$485 / 100μlE20-75086-AF790$485 / 100μlE20-75086-APC$485 / 100μlE20-75086-PE$485 / 100μlE20-75086-Cy3$485 / 100μlE20-75086-Cy5$485 / 100μlE20-75086-Cy5.5$485 / 100μlE20-75086-Cy7$485 / 100μlE20-75086-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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