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Cell Signal Transduction Research Antibodies
HNF-1β Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight61324Da
Protein NameHepatocyte nuclear factor 1-beta
Human Gene Id6928/6928
Human Swiss Prot NoP35680
Mouse Gene Id21410
Mouse Swiss Prot NoP27889
Rat Gene Id25640
Rat Swiss Prot NoP23899
SpecificityHNF-1β Polyclonal Antibody detects endogenous levels of HNF-1β protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameHNF1B; TCF2; Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; Homeoprotein LFB3; Transcription factor 2; TCF-2; Variant hepatic nuclear factor 1; vHNF1
Observed Band(KD)60
Functiondisease:A genetic variation in HNF1B is associated with susceptibility to hereditary prostate cancer type 11 (HPC11) [MIM:611955].,disease:Defects in HNF1B are a cause of Muellerian aplasia [MIM:158330]. In a Norwegian family with a novel syndrome of mild diabetes and severe non-diabetic renal disease, Muellerian aplasia expressed as vaginal aplasia and rudimentary uterus, were found in 2 females. These findings suggest that a broader spectrum of clinical symptoms may be associated with defects in HNF1B than previously recognized.,disease:Defects in HNF1B are the cause of maturity-onset diabetes of the young type 5 (MODY5) [MIM:604284]. MODY [MIM:606391] is a form of diabetes mellitus characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion.,disease:Defects in HNF1B are the cause of renal cysts and diabetes
Subcellular LocationNucleus.
ExpressionColon,Liver,Thalamus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the N-terminal region of human HNF-1β.
Gene NameHNF1B
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
BackgroundHNF1 homeobox B(HNF1B) Homo sapiens This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-75083-Conjugate. Price: $485 / Size: 100μl.
E20-75083-FITC$485 / 100μlE20-75083-Biotin$485 / 100μlE20-75083-HRP$485 / 100μlE20-75083-AP$485 / 100μlE20-75083-AF350$485 / 100μlE20-75083-AF405M$485 / 100μlE20-75083-AF488$485 / 100μlE20-75083-AF514$485 / 100μlE20-75083-AF532$485 / 100μlE20-75083-AF555$485 / 100μlE20-75083-AF568$485 / 100μlE20-75083-AF405S$485 / 100μlE20-75083-AF405L$485 / 100μlE20-75083-AF546$485 / 100μlE20-75083-AF594$485 / 100μlE20-75083-AF610$485 / 100μlE20-75083-AF635$485 / 100μlE20-75083-AF647$485 / 100μlE20-75083-AF680$485 / 100μlE20-75083-AF700$485 / 100μlE20-75083-AF750$485 / 100μlE20-75083-AF790$485 / 100μlE20-75083-APC$485 / 100μlE20-75083-PE$485 / 100μlE20-75083-Cy3$485 / 100μlE20-75083-Cy5$485 / 100μlE20-75083-Cy5.5$485 / 100μlE20-75083-Cy7$485 / 100μlE20-75083-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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