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Cell Signal Transduction Research Antibodies
SS-56 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight56259Da
Protein NameE3 ubiquitin-protein ligase TRIM68
Human Gene Id55128
Human Swiss Prot NoQ6AZZ1
Mouse Swiss Prot NoQ8K243
SpecificitySS-56 Polyclonal Antibody detects endogenous levels of SS-56 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTRIM68; GC109; RNF137; SS56; E3 ubiquitin-protein ligase TRIM68; RING finger protein 137; SSA protein SS-56; SS-56; Tripartite motif-containing protein 68
Observed Band(KD)56
Functiondisease:Target of immune response in patients with systemic lupus erythematosus (SLE), primary Sjoegren syndrome or HIV-1 infection.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,tissue specificity:Detected in all tissues. High expression is noted in spleen and in fetal liver.,
Subcellular LocationCytoplasm, perinuclear region. Nucleus. Colocalized with AR in nucleus.
ExpressionWidely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human SS-56.
Gene NameTRIM68
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/40000. Not yet tested in other applications.
Backgroundtripartite motif containing 68(TRIM68) Homo sapiens This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75082-Conjugate. Price: $485 / Size: 100μl.
E20-75082-FITC$485 / 100μlE20-75082-Biotin$485 / 100μlE20-75082-HRP$485 / 100μlE20-75082-AP$485 / 100μlE20-75082-AF350$485 / 100μlE20-75082-AF405M$485 / 100μlE20-75082-AF488$485 / 100μlE20-75082-AF514$485 / 100μlE20-75082-AF532$485 / 100μlE20-75082-AF555$485 / 100μlE20-75082-AF568$485 / 100μlE20-75082-AF405S$485 / 100μlE20-75082-AF405L$485 / 100μlE20-75082-AF546$485 / 100μlE20-75082-AF594$485 / 100μlE20-75082-AF610$485 / 100μlE20-75082-AF635$485 / 100μlE20-75082-AF647$485 / 100μlE20-75082-AF680$485 / 100μlE20-75082-AF700$485 / 100μlE20-75082-AF750$485 / 100μlE20-75082-AF790$485 / 100μlE20-75082-APC$485 / 100μlE20-75082-PE$485 / 100μlE20-75082-Cy3$485 / 100μlE20-75082-Cy5$485 / 100μlE20-75082-Cy5.5$485 / 100μlE20-75082-Cy7$485 / 100μlE20-75082-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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