Product Information
Molecular Weight122561Da
Protein NameUbiquitin conjugation factor E4 A
Human Gene Id9354
Human Swiss Prot NoQ14139
Rat Gene Id315608
Rat Swiss Prot NoQ6P7A2
SpecificityUBE4A Polyclonal Antibody detects endogenous levels of UBE4A protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameUBE4A; KIAA0126; Ubiquitin conjugation factor E4 A
Observed Band(KD)122
Functionfunction:Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the ubiquitin conjugation factor E4 family.,similarity:Contains 1 U-box domain.,
Subcellular LocationCytoplasm .
ExpressionBone marrow,Platelet,Skeletal muscle,
Backgroundubiquitination factor E4A(UBE4A) Homo sapiens This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011],