Product Information
Molecular Weight83542Da
Protein NameNuclear pore complex protein Nup88
Human Gene Id4927
Human Swiss Prot NoQ99567
Mouse Gene Id19069
Mouse Swiss Prot NoQ8CEC0
SpecificityNup88 Polyclonal Antibody detects endogenous levels of Nup88 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNUP88; Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88
Observed Band(KD)83
Functionfunction:Essential component of nuclear pore complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subunit:Interacts with NUP214/CAN.,tissue specificity:Ubiquitous.,
Subcellular LocationNucleus, nuclear pore complex .
ExpressionUbiquitous.
Backgroundnucleoporin 88(NUP88) Homo sapiens The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],