Myosin VI Polyclonal Antibody

Name: Myosin VI Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75072
Price: 225 USD
Availability: InStock

E20-75072Cite ID: EN0055205Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight149691Da

Protein NameUnconventional myosin-VI

Human Gene Id4646

Human Swiss Prot NoQ9UM54

Mouse Swiss Prot NoQ64331

SpecificityMyosin VI Polyclonal Antibody detects endogenous levels of Myosin VI protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameMYO6; KIAA0389; Unconventional myosin-VI; Unconventional myosin-6

Observed Band(KD)149

Functiondisease:Defects in MYO6 are the cause of non-syndromic sensorineural deafness autosomal dominant type 22 (DFNA22) [MIM:606346]. DFNA22 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA22 is progressive and postlingual, with onset during childhood. By the age of approximately 50 years, affected individuals invariably have profound sensorineural deafness.,disease:Defects in MYO6 are the cause of non-syndromic sensorineural deafness autosomal recessive type 37 (DFNB37) [MIM:607821].,disease:Defects in MYO6 are the cause of sensorineural deafness with hypertrophic cardiomyopathy (DFNHCM) [MIM:606346].,domain:Divided into three regions: a N-terminal motor (head) domain, followed by a neck domain consisting of a calmodulin-b

Subcellular LocationGolgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Golgi apparatus . Nucleus . Cytoplasm, perinuclear region . Membrane, clathrin-coated pit . Cytoplasmic vesicle, clathrin-coated vesicle . Cell projection, filopodium . Cell projection, ruffle membrane . Cell projection, microvillus . Cytoplasm, cytosol . Also present in endocyctic vesicles (PubMed:16507995). Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage (PubMed:16507995). Recruited into membrane ruffles from cell surface by EGF-stimulation (PubMed:9852149). Colocalizes with DAB2 in clathrin-coated pits/vesicles (PubMed:11967127). Colocalizes with OPTN at the Golgi complex and in vesicul

ExpressionExpressed in most tissues examined including heart, brain, placenta, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in brain, pancreas, testis and small intestine. Also expressed in fetal brain and cochlea. Isoform 1 and isoform 2, containing the small insert, and isoform 4, containing neither insert, are expressed in unpolarized epithelial cells.

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from Myosin VI . at AA range: 40-120

Gene NameMYO6

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/5000. Not yet tested in other applications.

Backgroundmyosin VI(MYO6) Homo sapiens This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75072-Conjugate. Price: $485 / Size: 100μl.

E20-75072-FITC$485 / 100μlE20-75072-Biotin$485 / 100μlE20-75072-HRP$485 / 100μlE20-75072-AP$485 / 100μlE20-75072-AF350$485 / 100μlE20-75072-AF405M$485 / 100μlE20-75072-AF488$485 / 100μlE20-75072-AF514$485 / 100μlE20-75072-AF532$485 / 100μlE20-75072-AF555$485 / 100μlE20-75072-AF568$485 / 100μlE20-75072-AF405S$485 / 100μlE20-75072-AF405L$485 / 100μlE20-75072-AF546$485 / 100μlE20-75072-AF594$485 / 100μlE20-75072-AF610$485 / 100μlE20-75072-AF635$485 / 100μlE20-75072-AF647$485 / 100μlE20-75072-AF680$485 / 100μlE20-75072-AF700$485 / 100μlE20-75072-AF750$485 / 100μlE20-75072-AF790$485 / 100μlE20-75072-APC$485 / 100μlE20-75072-PE$485 / 100μlE20-75072-Cy3$485 / 100μlE20-75072-Cy5$485 / 100μlE20-75072-Cy5.5$485 / 100μlE20-75072-Cy7$485 / 100μlE20-75072-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.