Product Information
Molecular Weight70682Da
Protein NameHepatocyte growth factor activator
Human Gene Id3083
Human Swiss Prot NoQ04756
Mouse Gene Id54426
Mouse Swiss Prot NoQ9R098
SpecificityHGFA Polyclonal Antibody detects endogenous levels of HGFA protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameHGFAC; Hepatocyte growth factor activator; HGF activator; HGFA
Observed Band(KD)70
Functioncaution:It is uncertain whether Met-1 is the initiator.,function:Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 fibronectin type-I domain.,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 kringle domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,subcellular location:Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.,subunit:Heterodimer of a short chain and a long chain linked by a disulfide bond.,tissue specificity:Liver.,
Subcellular LocationSecreted. Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
ExpressionLiver.
BackgroundHGF activator(HGFAC) Homo sapiens This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],